KARS Antibody, Biotin conjugated - Cat. #: CSB-PA04689D0Rb

SKU: CSB-PA04689D0Rb

Size :50ug

Clone Number:

Aliases:CMTRIB antibody; DFNB89 antibody; EC 6.1.1.6 antibody; KARS 1 antibody; KARS 2 antibody; KARS antibody; KARS1 antibody; KARS2 antibody; KIAA0070 antibody; KRS antibody; Lysine tRNA ligase antibody; Lysine--tRNA ligase antibody; LysRS antibody; Lysyl tRNA synthetase antibody; Lysyl-tRNA synthetase antibody; SYK_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q15046

Immunogen:Recombinant Human Lysine--tRNA ligase protein (101-400AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:9278442, PubMed:18029264, PubMed:18272479). When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:5338216, PubMed:14975237, PubMed:19524539, PubMed:23159739). (Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA3(Lys), the primer for reverse transcription initiation.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:KARS

Research Areas:Epigenetics and Nuclear Signaling