ITGA4 Antibody - Cat. #: CSB-PA011867LA01HU

SKU: CSB-PA011867LA01HU

Size :50ug

Clone Number:

Aliases:269C wild type antibody; Antigen CD49D, alpha 4 subunit of VLA 4 receptor antibody; CD49 antigen like family member D antibody; CD49 antigen-like family member D antibody; CD49d antibody; IA4 antibody; Integrin alpha 4 antibody; Integrin alpha 4 subunit antibody; Integrin alpha IV antibody; Integrin alpha-4 antibody; Integrin alpha-IV antibody; Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA 4 receptor) antibody; ITA4_HUMAN antibody; ITGA4 antibody; MGC90518 antibody; OTTHUMP00000205320 antibody; Very late activation protein 4 receptor, alpha 4 subunit antibody; VLA 4 subunit alpha antibody; VLA-4 subunit alpha antibody; VLA4 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P13612

Immunogen:Recombinant Human Integrin alpha-4 protein (376-558AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background:Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:ITGA4

Research Areas:Cardiovascular; Immunology; Signal transduction; Stem cells