IRAK1 Antibody - Cat. #: CSB-PA101009

SKU: CSB-PA101009

Size :100ul

Clone Number:

Aliases:AA48924 antibody; Il1rak antibody; Interleukin 1 receptor associated kinase 1 antibody; Interleukin-1 receptor-associated kinase 1 antibody; IRAK antibody; IRAK-1 antibody; Irak1 antibody; IRAK1-S antibody; IRAK1_HUMAN antibody; mPLK antibody; OTTHUMP00000026014 antibody; OTTHUMP00000026015 antibody; OTTHUMP00000026020 antibody; OTTHUMP00000180621 antibody; Pelle antibody; Pelle homolog antibody; Pelle-like protein kinase antibody; Plpk antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P51617

Immunogen:Synthesized peptide derived from Internal of Human IRAK1.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; IHC:1:50-1:100

Background:Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3.

Cao Z., Science 271:1128-1131(1996).
Reichwald K., Mamm. Genome 11:182-190(2000).
Jensen L.E., J. Biol. Chem. 276:29037-29044(2001).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:IRAK1

Research Areas:Cardiovascular;Immunology;Signal transduction