InVivoMAb Anti-Mouse CD8a/Lyt2 Antibody (Iv0165)

SKU: MF815010

Size:100ug

Description:Iv0165 is a rat IgG2a monoclonal antibody targeting CD8α. It is widely used to block CD8+ T cell activity in mice without depleting the cells in vivo. Functionally, Iv0165 can induce tolerance in xenograft transplantation models and reduce the incidence of insulin-dependent diabetes mellitus (IDDM) in NOD mice. Structurally, Iv0165 binds CD8α at residues that overlap with the class I pMHC binding site, including Glu6, Arg8, and Glu27, forming hydrogen bonds with specific antibody residues (e.g., TyrL53, TyrH100, AsnL32). By occupying this epitope, Iv0165 likely interferes with CD8α interactions with class I MHC and TL molecules, blocking T cell co-receptor function.

Host species:Rat

Species reactivity:Mouse

Form:Liquid

Storage buffer:0.01M PBS, pH 7.4.

Purity:>95% as determined by SDS-PAGE.

Clonality:Monoclonal

Isotype:IgG2a, kappa

Applications:Neutralization

Target:T-cell surface glycoprotein CD8 alpha chain, T-cell surface glycoprotein Lyt-2, CD8a, Cd8a, Lyt-2, Lyt2

Purification:Protein A/G purified from cell culture supernatant.

Endotoxin level:Please contact us for this information.

Accession:P01731

Stability and Storage:Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID:Iv0165

Product Usage Information:

Predicted molecular weight:

Note:For research use only. Not suitable for clinical or therapeutic use.