IL10 Antibody - Cat. #: CSB-PA011580KA01HU

SKU: CSB-PA011580KA01HU

Size :100ul

Clone Number:

Aliases:CSIF antibody; Cytokine synthesis inhibitory factor antibody; GVHDS antibody; IL 10 antibody; IL-10 antibody; IL10 antibody; IL10_HUMAN antibody; IL10A antibody; Interleukin 10 antibody; Interleukin-10 antibody; MGC126450 antibody; MGC126451 antibody; T-cell growth inhibitory factor antibody; TGIF antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P22301

Immunogen:Recombinant protein of Human IL10

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IHC; WB:1:500-1:2000, IHC:1:50-1:200

Background:IL-10 is an anti-inflammatory cytokine that is produced by T cells, NK cells and macrophages. IL-10 initiates signal transduction by binding to a cell surface receptor complex consisting of IL-10 RI and IL-10 RII. Binding of IL-10 leads to the activation of Jak1 and Tyk2, which phosphorylates Stat-3. The anti-inflammatory activity of IL-10 is due to its ability to block signaling through other cytokine receptors, notably IFN? receptor, by upregulating expression of SOCS-1. In addition, IL-10 promotes T cell tolerance by inhibiting tyrosine phosphorylation of CD28. IL-10 is an important negative regulator of the immune response, which allows for maintenance of pregnancy. In contrast, increased IL-10 levels contribute to persistent Leishmania major infections.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Affinity purification

Conjugate:Non-conjugated

Buffer:Store at -20°C or -80°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:IL10

Research Areas:Cancer;Immunology