IL-4 rabbit pAb

SKU: ES5878

Size: 100μL

Source:Rabbit

Applications:WB;Flow Cyt;ELISA

Reactivity:Human;Mouse

Dilution:WB 1:500-2000;Flow Cyt 1:50-200;ELISA 1:5000-20000

Immunogen:Synthesized peptide derived from the C-terminal region of human IL-4.

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):18kD

Human_gene_id:3565

Human_swiss_prot_no:P05112

Subcellular_location:Secreted.

Other_name:IL4; Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra

Background:The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],