IL-10 antibody , Cat. # FNab10822

SKU: FNab10822

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.)

Background:The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

Immunogen:interleukin 10

Synonyms:CSIF, IL 10, IL10, IL-10, IL10A, interleukin 10, TGIF

Observed MW:21 kDa

Uniprot ID:G3HB01

Reactivity:Hamster

Tested Application:ELISA, WB

Recommended dilution:WB: 1:500 - 1:2000

Gene ID:

Research Area:Immunology, Cardiovascular, Signal Transduction