IGF-I Receptor beta(Phospho-Tyr1131) Rabbit Polyclonal Antibody

SKU: BT-AP00099

Size:100μL

Background:This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Research_area: Signal transduction; Cancer; Developmental biology

Target_protein:IGF1R

applications:WB

Reactivity:Human, Rat, Mouse

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:IGF-1RB

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):

UniProt accession:Human: P08069; Mouse: Q60751; Rat: P24062

Synonyms:IGF-IRB; Insulin-like growth factor 1 receptor; EC 2.7.10.1; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain;

GeneID:Human: 3480; Mouse: 16001; Rat: 25718