Human UPF0510 protein INM02,C19orf63 ELISA KIT

SKU: E6390Hu

Size:96 Tests-1 Kit

Background:Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways (PubMed:28931551). {ECO:0000269|PubMed:28931551, ECO:0000269|PubMed:29242231, ECO:0000269|PubMed:29809151, ECO:0000269|PubMed:30415835, ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176, ECO:0000305}.

Research_area:

Applications:ELISA

Target_protein:EMC10

Reactivity:Human

Assay type:Sandwich

Sensitivity:14.33ng/L

Detection range:30-9000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:UPF0510 protein INM02

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q5UCC4

MASS(Da):27347

GeneID:284361

Synonyms:EMC10 C19orf63 INM02 UNQ764/PRO1556

Gene names:EMC10

Standard solution:9600ng/L