Human Tyrosine-protein Kinase Receptor Tyro3, TYRO3 ELISA Kit

SKU: E6363Hu

Size:96 Tests-1 Kit

Background:Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope.

Research_area:Neuroscience

Applications:ELISA

Target_protein:TYRO3

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.121ng/mL

Detection range:0.2-60ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Tyrosine-protein kinase receptor TYRO3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q06418

MASS(Da):96,905

GeneID:7301

Synonyms:BYK;Dtk;Rek;RSE;Sky;Tif;TYRO3;Tyrosine-protein kinase BYK;Tyrosine-protein kinase DTK;Tyrosine-protein kinase receptor TYRO3;Tyrosine-protein kinase RSE;Tyrosine-protein kinase SKY;Tyrosine-protein kinase TIF;

Gene names:TYRO3

Standard solution:64ng/mL