Human Tubulin Polymerization-promoting Protein, TPPP ELISA Kit

SKU: E3198Hu

Size:96 Tests-1 Kit

Background:Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed: 31522887). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (PubMed: 31522887). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (PubMed: 31522887). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (PubMed: 21995432, PubMed: 21316364). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed: 17105200, PubMed: 17693641, PubMed: 18028908, PubMed: 26289831). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (PubMed: 20308065, PubMed: 23093407). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (PubMed: 23093407). Plays a role in cell proliferation by regulating the G1/S-phase transition (PubMed: 23355470). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (PubMed: 22328514).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:TPPP

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.017ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Tubulin Polymerization-Promoting Protein

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O94811

MASS(Da):23,694

GeneID:11076

Synonyms:25 kDa brain-specific protein;p24;p25-alpha;TPPP;TPPP/p25;Tubulin polymerization-promoting protein

Gene names:TPPP

Standard solution:24ng/ml