Human Tryptase Gamma, TPSG1 ELISA Kit

SKU: E6330Hu

Size:96 Tests-1 Kit

Background:Tryptase gamma, also known as serine protease 31 or transmembrane tryptase, is an enzyme that in humans is encoded by the TPSG1 gene. Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. There is uncertainty regarding the number of genes in this cluster. Currently four functional genes - alpha I, beta I, beta II and gamma I - have been identified. And beta I has an allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gamma II. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. This gene differs from other members of the tryptase gene family in that it has C-terminal hydrophobic domain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.

Research_area:Tags & Cell Markers

Applications:ELISA

Target_protein:TPSG1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.058ng/mL

Detection range:0.1-40ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Tryptase gamma

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9NRR2

MASS(Da):33,815

GeneID:25823

Synonyms:PRSS31;Serine protease 31;TMT;TPSG1;Transmembrane tryptase;trpA;Tryptase gamma;Tryptase gamma heavy chain];Tryptase gamma light chain;

Gene names:TPSG1

Standard solution:48ng/mL