Human Tripartite Motif-containing Protein 35,TRIM35 ELISA KIT

SKU: E6686Hu

Size:96 Tests-1 Kit

Background:E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response. Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via DDX58/RIG-I signaling pathway (PubMed:32562145). Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2 (PubMed:32562145). Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway (PubMed:25907537). Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (PubMed:25263439). {ECO:0000269|PubMed:25263439, ECO:0000269|PubMed:25907537, ECO:0000269|PubMed:32562145}.

Research_area:

Applications:ELISA

Target_protein:TRIM35

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.93ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Tripartite Motif-containing Protein 35

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9UPQ4

MASS(Da):56540

GeneID:23087

Synonyms:TRIM35 HLS5 KIAA1098

Gene names:TRIM35

Standard solution:2400ng/L