Human Transmembrane Protease, Serine 2, TMPRSS2 ELISA Kit

SKU: E2625Hu

Size:96 Tests-1 Kit

Background:Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed: 25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed: 15537383, PubMed: 26018085, PubMed: 25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity). (Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry (PubMed: 24227843, PubMed: 32142651, PubMed: 32404436). Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.

Research_area:Neuroscience

Applications:ELISA

Target_protein:TMPRSS2

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.044ng/ml

Detection range:0.1-35ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Transmembrane Protease, Serine 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O15393

MASS(Da):53,859

GeneID:7113

Synonyms:Serine protease 10;TMPRSS 2;TMPRSS2;Transmembrane protease serine 2;Transmembrane protease serine 2 catalytic chain;Transmembrane protease serine 2 non-catalytic chain

Gene names:TMPRSS2

Standard solution:40ng/ml