Human Transient receptor potential cation channel subfamily M member 8,TRPM8 ELISA KIT

SKU: E3735Hu

Size:96 Tests-1 Kit

Background:Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration (PubMed:25559186). Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel. {ECO:0000269|PubMed:15306801, ECO:0000269|PubMed:16174775, ECO:0000269|PubMed:22128173, ECO:0000269|PubMed:25559186}.

Research_area:

Applications:ELISA

Target_protein:TRPM8

Reactivity:Human

Assay type:Sandwich

Sensitivity:18.41pg/ml

Detection range:37.5-2400pg/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Transient Receptor Potential Cation Channel Subfamily M,Member 8

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q7Z2W7

MASS(Da):127685

GeneID:79054

Synonyms:TRPM8 LTRPC6 TRPP8

Gene names:TRPM8

Standard solution:4800pg/ml