Human Transforming Growth Factors Β2, TGFB2 ELISA Kit

SKU: E0067Hu

Size:96 Tests-1 Kit

Background:Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated Peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. [Latency-associated Peptide]: Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 (By similarity). Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (PubMed: 22772371, PubMed: 22772368). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated Peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus (By similarity). Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:TGFB2

Reactivity:Human

Assay type:Sandwich

Sensitivity:3.53ng/L

Detection range:7-1500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Transforming Growth Factors beta2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P61812

MASS(Da):47,748

GeneID:7042

Synonyms:Cetermin;Glioblastoma-derived T-cell suppressor factor;G-TSF;LAP;Latency-associated Peptide;TGF B2;TGF beta2;TGFB 2;TGFB2;TGF-beta-2;Transforming growth factor beta-2;Transforming growth factor beta-2 proprotein

Gene names:TGFB2

Standard solution:1600ng/L