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GeneBio Systems

Human Transcription Initiation Factor IIB, GTF2B ELISA Kit

Human Transcription Initiation Factor IIB, GTF2B ELISA Kit

E2709Hu

$847.00 USD
$847.00 USD
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Size:96 Tests-1 Kit

Background:General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA (PubMed:1876184, PubMed:1946368, PubMed:1517211, PubMed:3818643, PubMed:3029109, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:7601352, PubMed:9420329, PubMed:12931194, PubMed:27193682). Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex (PubMed:8504927, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312). Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle (PubMed:7601352). Associates with chromatin to core promoter-specific regions (PubMed:12931194, PubMed:24441171). Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element (PubMed:9420329, PubMed:16230532, PubMed:7675079, PubMed:10619841). Modulates transcription start site selection (PubMed:10318856). Exhibits also autoacetyltransferase activity that contributes to the activated transcription (PubMed:12931194).

Research_area:Others

Applications:ELISA

Target_protein:GTF2B

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.77ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Transcription initiation factor IIB

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q00403

MASS(Da):34,833

GeneID:2959

Synonyms:General transcription factor TFIIB;GTF2B;S300-II;TF2B;TFIIB;Transcription initiation factor IIB

Gene names:GTF2B

Standard solution:2400ng/L

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