Human Transcription Factor Hivep3, HIVEP3 ELISA Kit

SKU: E6288Hu

Size:96 Tests-1 Kit

Background:Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation.

Research_area:Others

Applications:ELISA

Target_protein:HIVEP3

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.41ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Transcription factor HIVEP3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q5T1R4

MASS(Da):259,465

GeneID:59269

Synonyms:HIVEP3;Human immunodeficiency virus type I enhancer-binding protein 3;Kappa-B and V(DJ recombination signal sequences-binding protein;Kappa-binding protein 1;KBP1;KBP-1;KRC;SHN3;Transcription factor HIVEP3;ZAS3;Zinc finger protein ZAS3;ZNF40C

Gene names:HIVEP3

Standard solution:4800ng/L