Human Transcription Factor A, Mitochondrial, TFAM ELISA Kit

SKU: E6726Hu

Size:96 Tests-1 Kit

Background:Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (PubMed: 29445193, PubMed: 32183942). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed: 29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed: 20410300). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase (PubMed: 22037172). Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites (PubMed: 22037172). Is able to unwind DNA (PubMed: 22037172). Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes (PubMed: 1737790). Required for maintenance of normal levels of mitochondrial DNA (PubMed: 22841477, PubMed: 19304746). May play a role in organizing and compacting mitochondrial DNA (PubMed: 22037171).

Research_area:Tags & Cell Markers

Applications:ELISA

Target_protein:TFAM

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.17ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Transcription Factor A,Mitochondrial

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q00059

MASS(Da):29,097

GeneID:7019

Synonyms:Mitochondrial transcription factor 1;MtTF1;mtTFA;TCF-6;TFAM;Transcription factor 6;Transcription factor 6-like 2;Transcription factor A, mitochondrial

Gene names:TFAM

Standard solution:2400ng/L