Human Transcription Factor 7 Like Protein 2,TCF7L2 ELISA KIT

SKU: E7309Hu

Size:96 Tests-1 Kit

Background:Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. {ECO:0000269|PubMed:12408868, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:19443654, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:9727977}.

Research_area:

Applications:ELISA

Target_protein:TCF7L2

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.019ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Transcription Factor 7 Like Protein 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9NQB0

MASS(Da):67919

GeneID:6934

Synonyms:TCF7L2 TCF4

Gene names:TCF7L2

Standard solution:24ng/ml