Human TRAIL / CD253 ELISA Kit PicoKine®

SKU: EK0532

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: TNFSF10

Specificity: Natural and recombinant human TRAIL

Background: In the field of cell biology, TNF-related apoptosis-inducing ligand (TRAIL), is a protein which functions as a ligand which induces the process of cell death called apoptosis. TRAIL has also been designated CD253 (cluster of differentiation 253).Tumor necrosis factor (TNF) family cytokines function as prominent mediators of immune regulation and the inflammatory response. Most TNF family cytokines are expressed as type II transmembrane proteins, with homology confined to approximately 150 C-terminal residues. The TNF ligands interact with a parallel family of receptors. TRAIL binds to the death receptors DR4 (TRAIL-RI) and DR5 (TRAIL-RII). The process of apoptosis is caspase-8-dependent. Caspase-8 activates downstream effector caspases including procaspase-3, -6, and -7, leading to activation of specific kinases. TRAIL also binds the receptors DcR1 and DcR2, which do not contain a cytoplasmic domain (DcR1) or contain a truncated death domain (DcR2). The standard product used in this kit is recombinant human TRAIL with the molecular mass of 21KDa. It is expressed from the amino acids ectoderm T95--G28.

Immunogen: Expression system for standard: NS0; Immunogen sequence: T95-G281

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Uniprot ID: P50591

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 8743

Protein Name: Tumor necrosis factor ligand superfamily member 10

Gene Full Name: TNF superfamily member 10

Synonyms: Apo 2 ligand; Apo 2L; APO2L; CD253; Protein TRAIL; TL2; TNFSF10; TRAIL