Human Toll-like Receptor 9, TLR-9 ELISA Kit

SKU: E0356Hu

Size:96 Tests-1 Kit

Background:Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed: 11564765, PubMed: 17932028). Controls lymphocyte response to Helicobacter infection (By similarity). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (PubMed: 23857366).

Research_area:Immunology; Signal Transduction

Applications:ELISA

Target_protein:TLR9

Reactivity:Human

Assay type:Sandwich

Sensitivity:2.53ng/L

Detection range:5-1500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Toll-Like Receptor 9

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9NR96

MASS(Da):115,860

GeneID:54106

Synonyms:CD antigen CD289;TLR 9;TLR9;Toll-like receptor 9

Gene names:TLR9

Standard solution:1600ng/L