Human Toll-like Receptor 7, TLR7 ELISA Kit

SKU: E0334Hu

Size:96 Tests-1 Kit

Background:Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed: 14976261, PubMed: 32433612). Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs (PubMed: 31608988, PubMed: 27742543, PubMed: 12738885). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed: 27742543). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively (PubMed: 27742543).

Research_area:Immunology; Signal Transduction; Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:TLR7

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.32ng/L

Detection range:10-3500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Toll-Like Receptor 7

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9NYK1

MASS(Da):120,922

GeneID:51284

Synonyms:TLR 7;TLR7;Toll-like receptor 7

Gene names:TLR7

Standard solution:4000ng/L