Human Suppressors of Cytokine Signaling 3, SOCS-3 ELISA Kit

SKU: E0657Hu

Size:96 Tests-1 Kit

Background:SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed: 15601820).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:SOCS3

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.02ng/L

Detection range:20-6000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Suppressors of Cytokine Signaling 3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O14543

MASS(Da):24,770

GeneID:9021

Synonyms:CIS-3;Cytokine-inducible SH2 protein 3;SOCS 3;SOCS3;SOCS-3;SSI-3;STAT-induced STAT inhibitor 3;Suppressor of cytokine signaling 3

Gene names:SOCS3

Standard solution:6400ng/L