Human Sulfotransferase 1A1, SULT1A1 ELISA Kit

SKU: E6231Hu

Size:96 Tests-1 Kit

Background:Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine groupe. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones and 3,3'-diiodothyronin (PubMed:16221673, PubMed:12471039, PubMed:22069470, PubMed:21723874, PubMed:10199779, PubMed:7834621). Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil (By similarity). Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed:7834621).

Research_area:Others

Applications:ELISA

Target_protein:SULT1A1

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.65ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Sulfotransferase 1A1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P50225

MASS(Da):34,165

GeneID:6817

Synonyms:Aryl sulfotransferase 1;HAST1/HAST2;Phenol sulfotransferase 1;Phenol-sulfating phenol sulfotransferase 1;P-PST;P-PST 1;PST;ST1A1;ST1A3;STP;STP1;Sulfotransferase 1A1;SULT1A1;Thermostable phenol sulfotransferase;ts-PST

Gene names:SULT1A1

Standard solution:3200ng/L