Human Stromal Interaction Molecule 1, STIM1 ELISA Kit

SKU: E6228Hu

Size:96 Tests-1 Kit

Background:Stromal interaction molecule 1 is a protein that in humans is encoded by the STIM1 gene. STIM1 has a single transmembrane domain, and is localized to the endoplasmic reticulum, and to a lesser extent to the plasma membrane. Even though the protein has been identified earlier, its function was unknown until recently. In 2005, it was discovered that STIM1 functions as a calcium sensor in the endoplasmic reticulum. Upon activation of the IP3 receptor, the calcium concentration in the endoplasmic reticulum decreases, which is sensed by STIM1, via its EF hand domain. STIM1 activates the "store-operated" ORAI1 calcium ion channels in the plasma membrane, via intracellular STIM1 movement, clustering under plasma membrane and protein interaction with ORAI isoforms. STIM1-mediated calcium entry is required for thrombin-induced disassembly of VE-cadherin adherens junctions. 2-Aminoethoxydiphenyl borate (2-APB) and 4-chloro-3-ethylphenol (4-CEP) cause STIM1 clustering in a cell and prevent STIM1 moving toward plasma membrane.

Research_area:Others

Applications:ELISA

Target_protein:STIM1

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.26ng/L

Detection range:20-6000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Stromal interaction molecule 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q13586

MASS(Da):77,423

GeneID:6786

Synonyms:D11S4896E;GOK;IMD10;STIM1;STRMK;Stromal interaction molecule 1;TAM;TAM1

Gene names:STIM1

Standard solution:6400ng/L