Human Sortilin, SORT1 ELISA Kit

SKU: E3966Hu

Size:96 Tests-1 Kit

Background:Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed: 16787399). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.

Research_area:Cardiovascular

Applications:ELISA

Target_protein:SORT1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.024ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Sortilin

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q99523

MASS(Da):92,068

GeneID:6272

Synonyms:100 kDa NT receptor;Glycoprotein 95;Gp95;Neurotensin receptor 3;NT3;NTR3;SORT 1;SORT1;Sortilin;

Gene names:SORT1

Standard solution:24ng/ml