Human Soluble Programmed Cell Death-1 Ligand-1,CD274;PDL1 ELISA KIT

SKU: E4829Hu

Size:96 Tests-1 Kit

Background:Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813417, PubMed:28813410). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417}.; The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28813417, PubMed:28813410). The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (By similarity). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (By similarity). {ECO:0000250|UniProtKB:Q9EP73, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417}.

Research_area:

Applications:ELISA

Target_protein:CD274

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.55ng/ml

Detection range:1.25-80ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Soluble Programmed Cell Death-1 Ligand-1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9NZQ7

MASS(Da):33275

GeneID:29126

Synonyms:CD274 B7H1 PDCD1L1 PDCD1LG1 PDL1

Gene names:CD274

Standard solution:160ng/ml