Human Small Ubiquitin-related Modifier 2, SUMO2 ELISA Kit

SKU: E6184Hu

Size:96 Tests-1 Kit

Background:Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed: 26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed: 18408734, PubMed: 18538659, PubMed: 21965678, PubMed: 9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed: 24105744).

Research_area:Cell Biology

Applications:ELISA

Target_protein:SUMO2

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.26ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Small Ubiquitin-Related Modifier 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P61956

MASS(Da):10,871

GeneID:6613

Synonyms:HSMT3;Sentrin-2;Small ubiquitin-related modifier 2;SMT3 homolog 2;Smt3B;SUMO 2;SUMO2;SUMO-2;SUMO-3;Ubiquitin-like protein SMT3B

Gene names:SUMO2

Standard solution:2400ng/L