Human Signal Transducer and Activator of Transcription 2, STAT2 ELISA Kit

SKU: E0675Hu

Size:96 Tests-1 Kit

Background:Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734). In addition, has also a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs (PubMed:28165510). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121, PubMed:23391734, PubMed:9020188).

Research_area:Signal Transduction; Epigenetics and Nuclear Signaling; Microbiology

Applications:ELISA

Target_protein:STAT2

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.019ng/ml

Detection range:0.05-10ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:signal transducer and activator of transcription 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P52630

MASS(Da):97,916

GeneID:6773

Synonyms:IMD44;ISGF-3;P113;PTORCH3;Signal transducer and activator of transcription 2;STAT113;STAT2

Gene names:STAT2

Standard solution:12.8ng/ml