Human Serine Protease Htra1, HTRA1 ELISA Kit

SKU: E2746Hu

Size:96 Tests-1 Kit

Background:Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:HTRA1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.23ng/mL

Detection range:0.5-200ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Serine protease HTRA1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q92743

MASS(Da):51,287

GeneID:5654

Synonyms:ARMD7;CARASIL;High-temperature requirement A serine peptidase 1;HtrA;HTRA1;L56;ORF480;PRSS11;Serine protease 11;Serine protease HTRA1

Gene names:HTRA1

Standard solution:240ng/mL