Human Securin, PTTG1 ELISA Kit

SKU: E6132Hu

Size:96 Tests-1 Kit

Background:Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.

Research_area:Cancer

Applications:ELISA

Target_protein:PTTG1

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.74ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Securin

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O95997

MASS(Da):22,024

GeneID:9232

Synonyms:Esp1-associated protein;hPTTG;Pituitary tumor-transforming gene 1 protein;PTTG 1;PTTG1;Securin;Tumor-transforming protein 1

Gene names:PTTG1

Standard solution:4800ng/L