Human Secretory leukocyte protease inhibitor,SLPI ELISA KIT

SKU: E0850Hu

Size:96 Tests-1 Kit

Background:Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G (PubMed:3533531, PubMed:3462719, PubMed:2039600, PubMed:2110563, PubMed:10702419, PubMed:24121345). Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses (PubMed:10702419, PubMed:24352879). Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to infection by L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (By similarity). Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells (PubMed:24352879). {ECO:0000250|UniProtKB:P97430, ECO:0000269|PubMed:10702419, ECO:0000269|PubMed:2039600, ECO:0000269|PubMed:2110563, ECO:0000269|PubMed:24121345, ECO:0000269|PubMed:24352879, ECO:0000269|PubMed:3462719, ECO:0000269|PubMed:3533531, ECO:0000305}.

Research_area:

Applications:ELISA

Target_protein:SLPI

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.51ng/ml

Detection range:1-64ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:secretory leukocyte protease inhibitor

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P03973

MASS(Da):14326

GeneID:6590

Synonyms:SLPI WAP4 WFDC4

Gene names:SLPI

Standard solution:128ng/ml