Human Ribonuclease 3, RNASEN ELISA Kit

SKU: E2404Hu

Size:96 Tests-1 Kit

Background:Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:DROSHA

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.023ng/ml

Detection range:0.05-10ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Ribonuclease 3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9NRR4

MASS(Da):159,316

GeneID:29102

Synonyms:DROSHA;p241;Protein Drosha;Ribonuclease 3;Ribonuclease III;RNase III

Gene names:DROSHA

Standard solution:16ng/ml