Human Rho Guanine Nucleotide Exchange Factor 1, ARHGEF1 ELISA Kit

SKU: E3234Hu

Size:96 Tests-1 Kit

Background:Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed: 9641915, PubMed: 9641916). Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed: 9641915, PubMed: 9641916, PubMed: 8810315, PubMed: 30521495). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed: 9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed: 9641916). Mediates angiotensin-2-induced RhoA activation (PubMed: 20098430).

Research_area:Others

Applications:ELISA

Target_protein:ARHGEF1

Reactivity:Human

Assay type:Sandwich

Sensitivity:2.79ng/L

Detection range:5-1000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Rho Guanine Nucleotide Exchange Factor 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q92888

MASS(Da):102,435

GeneID:9138

Synonyms:115 kDa guanine nucleotide exchange factor;ARHGEF 1;ARHGEF1;p115RhoGEF;p115-RhoGEF;Rho guanine nucleotide exchange factor 1;Sub1.5

Gene names:ARHGEF1

Standard solution:1280ng/L