Human Receptor-type Tyrosine-protein Phosphatase Eta, PTPRJ ELISA Kit

SKU: E1601Hu

Size:96 Tests-1 Kit

Background:Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:PTPRJ

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.029ng/ml

Detection range:0.05-30ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Receptor-type tyrosine-protein phosphatase eta

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q12913

MASS(Da):145,941

GeneID:5795

Synonyms:CD antigen CD148;CD148;Density-enhanced phosphatase 1;DEP1;DEP-1;HPTP eta;HPTPeta;Protein-tyrosine phosphatase eta;Protein-tyrosine phosphatase receptor type J;PTPRJ;Receptor-type tyrosine-protein phosphatase eta;R-PTP-ETA;R-PTP-J;SCC1

Gene names:PTPRJ

Standard solution:32ng/ml