Human Ras Association Domain-containing Protein 1, RASSF1 ELISA Kit

SKU: E6930Hu

Size:96 Tests-1 Kit

Background:Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.

Research_area:Cell Biology

Applications:ELISA

Target_protein:RASSF1

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.01ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Ras Association Domain-Containing Protein 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9NS23

MASS(Da):39,219

GeneID:11186

Synonyms:Ras association domain-containing protein 1;RASSF 1;RASSF1

Gene names:RASSF1

Standard solution:2400ng/L