Human RAR-related orphan receptor B,RORB ELISA KIT

SKU: E6885Hu

Size:96 Tests-1 Kit

Background:Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity). {ECO:0000250|UniProtKB:P45446}.; Isoform 1 is critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4 (By similarity). {ECO:0000250|UniProtKB:Q8R1B8}.

Research_area:

Applications:ELISA

Target_protein:RORB

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.36ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:RAR-related orphan receptor B

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q92753

MASS(Da):53220

GeneID:

Synonyms:RORB NR1F2 RZRB

Gene names:RORB

Standard solution:3200ng/L