Human Radical S-Adenosyl Methionine Domain-containing Protein 2, RSAD2 ELISA Kit

SKU: E6054Hu

Size:96 Tests-1 Kit

Background:Interferon-inducible antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon (PubMed:31812350). Catalyzes the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) via a SAM-dependent radical mechanism (PubMed:29925952, PubMed:30872404). In turn, ddhCTP acts as a chain terminator for the RNA-dependent RNA polymerases from multiple viruses and directly inhibits viral replication (PubMed:29925952). Therefore, inhibits a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), zika virus, and human immunodeficiency virus (HIV-1) (PubMed:29925952, PubMed:30587778, PubMed:31921110, PubMed:30934824). Promotes also TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating 'Lys-63'-linked ubiquitination of IRAK1 by TRAF6 (PubMed:30872404). Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins.

Research_area:Others

Applications:ELISA

Target_protein:RSAD2

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.65ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Radical S-adenosyl methionine domain-containing protein 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8WXG1

MASS(Da):42,170

GeneID:91543

Synonyms:cig33;cig5;Cytomegalovirus-induced gene 5 protein;Radical S-adenosyl methionine domain-containing protein 2;RSAD2;vig1;Viperin;Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible

Gene names:RSAD2

Standard solution:3200ng/L