Human R-Spondin-2, RSPO2 ELISA Kit

SKU: E6108Hu

Size:96 Tests-1 Kit

Background:Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (PubMed: 21909076, PubMed: 21727895, PubMed: 22615920). During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (PubMed: 29769720).

Research_area:Developmental Biology

Applications:ELISA

Target_protein:RSPO2

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.026ng/mL

Detection range:0.05-20ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:R-Spondin-2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q6UXX9

MASS(Da):28,315

GeneID:340419

Synonyms:hRspo2;Roof plate-specific spondin-2;RSPO 2;RSPO2;R-spondin-2

Gene names:RSPO2

Standard solution:24ng/mL