Human pyridoxal;pyridoxine vitamin B6-phosphatase,PDXP ELISA KIT

SKU: E0744Hu

Size:96 Tests-1 Kit

Background:Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism (PubMed:14522954, PubMed:8132548). Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine (PubMed:15580268). {ECO:0000269|PubMed:14522954, ECO:0000269|PubMed:15580268, ECO:0000269|PubMed:8132548}.

Research_area:

Applications:ELISA

Target_protein:PDXP

Reactivity:Human

Assay type:Sandwich

Sensitivity:1.98ng/ml

Detection range:3.75-240ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:pyridoxal;pyridoxine vitamin B6-phosphatase

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q96GD0

MASS(Da):31698

GeneID:57026

Synonyms:PDXP CIN PLP PLPP

Gene names:PDXP

Standard solution:480ng/ml