Human Protein Phosphatase, Mg2+, Mn2+ Dependent 1D, PPM1D ELISA Kit

SKU: E7328Hu

Size:96 Tests-1 Kit

Background:Involved in the negative regulation of p53 expression (PubMed: 23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed: 15870257, PubMed: 16311512). Mediates MAPK14 dephosphorylation and inactivation (PubMed: 21283629). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:PPM1D

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.019ng/ml

Detection range:0.05-15ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Protein Phosphatase, Mg2+/Mn2+ Dependent 1D

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O15297

MASS(Da):66,675

GeneID:8493

Synonyms:p53-induced protein phosphatase 1;PP2C-delta;PPM 1D;PPM1D;Protein phosphatase 1D;Protein phosphatase 2C isoform delta;Protein phosphatase magnesium-dependent 1 delta

Gene names:PPM1D

Standard solution:16ng/ml