Human Protein inhibitor of activated STAT3,PIAS3 ELISA KIT

SKU: E0634Hu

Size:96 Tests-1 Kit

Background:Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376). {ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24651376, ECO:0000269|PubMed:25406032, ECO:0000269|PubMed:9388184}.

Research_area:

Applications:ELISA

Target_protein:PIAS3

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.1ng/mL

Detection range:0.19-12ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Protein inhibitor of activated STAT3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Y6X2

MASS(Da):68017

GeneID:10401

Synonyms:PIAS3

Gene names:PIAS3

Standard solution:24ng/mL