Human Proteasome Activator Complex Subunit 3, PSME3 ELISA Kit

SKU: E5949Hu

Size:96 Tests-1 Kit

Background:Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978).

Research_area:Cell Biology; Immunology; Cancer

Applications:ELISA

Target_protein:PSME3

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.48ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Proteasome activator complex subunit 3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P61289

MASS(Da):29,506

GeneID:10197

Synonyms:11S regulator complex subunit gamma;Activator of multicatalytic protease subunit 3;HEL-S-283;Ki;Ki nuclear autoantigen;PA28G;PA28gamma;PA28-gamma;Proteasome activator 28 subunit gamma;Proteasome activator complex subunit 3;PSME3;REG-GAMMA

Gene names:PSME3

Standard solution:2400ng/L