Human Proline-serine-threonine Phosphatase-interacting Protein 1, PSTPIP1 ELISA Kit

SKU: E5933Hu

Size:96 Tests-1 Kit

Background:Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.

Research_area:Signal Transduction; Cancer; Cardiovascular

Applications:ELISA

Target_protein:PSTPIP1

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.34ng/L

Detection range:20-3500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Proline-serine-threonine phosphatase-interacting protein 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O43586

MASS(Da):47,591

GeneID:9051

Synonyms:CD2-binding protein 1;CD2BP1;CD2BP1L;CD2BP1S;H-PIP;PAPAS;PEST phosphatase-interacting protein 1;Proline-serine-threonine phosphatase-interacting protein 1;PSTPIP;PSTPIP1

Gene names:PSTPIP1

Standard solution:4000ng/L