Human Programmed Cell Death 6-interacting Protein, PDCD6IP ELISA Kit

SKU: E5922Hu

Size:96 Tests-1 Kit

Background:Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed: 14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed: 17853893, PubMed: 17556548). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed: 17853893, PubMed: 17556548, PubMed: 18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed: 22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity). (Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses).

Research_area:Cell Biology

Applications:ELISA

Target_protein:PDCD6IP

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.35ng/L

Detection range:20-6000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Programmed Cell Death 6-Interacting Protein

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8WUM4

MASS(Da):96,023

GeneID:10015

Synonyms:ALG-2-interacting protein 1;ALG-2-interacting protein X;Hp95;PDCD 6IP;PDCD6-interacting protein;PDCD6IP;Programmed cell death 6-interacting protein

Gene names:PDCD6IP

Standard solution:6400ng/L