Human Presenilin 2, PS-2 ELISA Kit

SKU: E0980Hu

Size:96 Tests-1 Kit

Background:Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak Channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed: 16959576). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed: 21285369).

Research_area:Neuroscience

Applications:ELISA

Target_protein:PSEN2

Reactivity:Human

Assay type:Sandwich

Sensitivity:2.47ng/L

Detection range:5-1000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Presenilin 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P49810

MASS(Da):50,140

GeneID:5664

Synonyms:AD3LP;AD5;E5-1;Presenilin-2;Presenilin-2 CTF subunit;Presenilin-2 NTF subunit;PS-2;PSEN 2;PSEN2;STM-2

Gene names:PSEN2

Standard solution:1280ng/L