Human Polymeric Immunoglobulin Receptor Secretory Component, PIGR ELISA Kit

SKU: E0320Hu

Size:96 Tests-1 Kit

Background:Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens (PubMed:12150896). On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells (PubMed:16543244).

Research_area:Others

Applications:ELISA

Target_protein:PIGR

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.51ng/ml

Detection range:1-300ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:polymeric immunoglobulin receptor/secretory component

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P01833

MASS(Da):83,284

GeneID:5284

Synonyms:Hepatocellular carcinoma-associated protein TB6;IGHA;IGHA1;IGHA2;PIGR;Poly-Ig receptor;Polymeric immunoglobulin receptor;Secretory component]

Gene names:PIGR

Standard solution:320ng/ml