Human Plasma Serine Protease Inhibitor, SERPINA5 ELISA Kit

SKU: E5882Hu

Size:96 Tests-1 Kit

Background:Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue- and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid.

Research_area:Others

Applications:ELISA

Target_protein:SERPINA5

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.029ng/mL

Detection range:0.05-20ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Plasma Serine Protease Inhibitor

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P05154

MASS(Da):45,675

GeneID:5104

Synonyms:Acrosomal serine protease inhibitor;PAI3;PAI-3;PCI;Plasma serine protease inhibitor;Plasminogen activator inhibitor 3;Protein C inhibitor;Serpin A5;SERPINA 5;SERPINA5

Gene names:SERPINA5

Standard solution:24ng/mL