Human Peroxiredoxin 6, PRDX6 ELISA Kit

SKU: E2929Hu

Size:96 Tests-1 Kit

Background:Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:9497358, PubMed:10893423). Can reduce H2O2 and short chain organic, fatty acid, and phospholipid hydroperoxides (PubMed:10893423). Also has phospholipase activity, can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (PubMed:10893423, PubMed:26830860). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (PubMed:10893423). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (PubMed:10893423). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:26830860). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (PubMed:26830860).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:PRDX6

Reactivity:Human

Assay type:Sandwich

Sensitivity:3.85ng/L

Detection range:7-1500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Peroxiredoxin 6

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P30041

MASS(Da):25,035

GeneID:9588

Synonyms:1-Cys;1-Cys peroxiredoxin;1-Cys PRX;24 kDa protein;Acidic calcium-independent phospholipase A2;aiPLA2;Antioxidant protein 2;AOP2;Glutathione-dependent peroxiredoxin;HEL-S-128m;Liver 2D page spot 40;LPC acyltransferase 5;LPCAT-5;Lyso-PC acyltransferase 5;Lysophosphatidylcholine acyltransferase 5;Non-selenium glutathione peroxidase;NSGPx;p29;Peroxiredoxin-6;PRDX6;PRX;Red blood cells page spot 12;

Gene names:PRDX6

Standard solution:1600ng/L